Magic Targets for Magic Bullets
نویسندگان
چکیده
منابع مشابه
PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets
The pharmacological inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) have reached the first milestone toward their inclusion in the arsenal of anti-cancer drugs by showing consistent benefits in clinical trials against BRCA-mutant cancers that are deficient in the homologous recombination repair (HRR) of DNA double strand breaks (DSB) (1, 2). PARP inhibitors (PARPi) also potentiate therapeut...
متن کاملImmunoconjugates : " Magic Bullets " for Cancer Therapy ?
Conjugating cytotoxic agents to antibodies allows for site-specific delivery of the agent to tumor cells and should provide increased efficacy and reduced non-specific toxicity. These site-specific cpotogc agents are known as irnmunoconjugates or "magic bullets" and have demonstrated great promise as therapeutic agents for cancer and other diseases. The historical developments and future potent...
متن کاملAntibodies – The “Magic Bullets” for Drug Delivery?
Abbreviations: Ab/Abs: Antibody/Antibodies; CD19: Cluster of Differentiation antigen associated with B-lymphocyte Antigen; CD4: Cluster of Differentiation glycoprotein on the surface of e.g., helper T cells; DNA: Deoxyribonucleic Acid; EGF/r3: Anti-epidermal growth factor receptor; Fc: “Fragment crystallizable” of the Ab molecule; FcRn: The neonatal Fc receptor; IgG1: Immunoglobulin G1; mAb: Mo...
متن کاملRadioimmunotherapy of Non-Hodgkin’s Lymphoma: From the ‘Magic Bullets’ to ‘Radioactive Magic Bullets’
Radioimmunotherapy (RIT) of lymphoma with Zevalin and Bexxar was approved by FDA in 2002 and 2003, respectively, for the treatment of relapsed or refractory CD20+ follicular B-cell non-Hodgkin´s lymphoma. In 2009, Zevalin was also approved for consolidation therapy in patients with follicular non-Hodgkin's lymphoma that achieve a partial or complete response to first-line chemotherapy. For foll...
متن کاملSmall non-coding RNAs as magic bullets.
RNA interference (RNAi) - inhibition of gene expression by small, non-coding RNAs [small interfering RNAs (siRNAs) or microRNAs (miRNAs)] - has changed our view of regulation of expression dramatically. The application of siRNAs for both functional analysis of genes and medication raises several questions. These include the design of the double-stranded oligonucleotides, their preparation and i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Oncology Research and Reports
سال: 2020
ISSN: 2693-4787
DOI: 10.31579/2693-4787/003